Spermidine is a naturally occurring polyamine compound found in all living organisms. It plays an essential role in various biological processes, including cellular growth, proliferation, and maintenance. Spermidine is derived from putrescine, another polyamine, and is a precursor for the production of spermine, another polyamine essential for cellular function.
Supplements & Potential Health Benefits
Spermidine supplements are increasingly marketed as anti-aging products, aiming to boost autophagy and support overall health. However, while initial studies in animals and some human trials show promise, further research is needed to fully understand its effects and safety profile.
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Always consult with a healthcare professional before starting new supplements, especially if you have preexisting conditions or are taking medications.
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Research suggests that spermidine supplementation or a spermidine-rich diet may offer benefits such as:
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Improved cardiovascular health
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Enhanced cognitive function and neuroprotection
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Better metabolic health
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Protection against age-related diseases like Alzheimer's and Parkinson's
Dietary Sources of Spermidine:
Spermidine is present in various foods, especially:
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Wheat germ
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Soybeans
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Mushrooms
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Cheese (aged varieties)
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Legumes
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Whole grains
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Broccoli
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Cauliflower
Key Functions of Spermidine:
Autophagy Stimulation:
Spermidine has been shown to induce autophagy, a process where cells clean out damaged components and regenerate, promoting cellular health and longevity.
Cell Growth and Proliferation:
Spermidine plays a critical role in cell division and tissue repair.
Anti-Aging Properties:
By enhancing autophagy and reducing oxidative stress, spermidine is believed to slow the aging process and support cellular resilience.
Immune Support:
Emerging research suggests spermidine might enhance immune function by promoting the health of immune cells.
DNA Stabilisation:
It helps stabilise DNA and RNA by binding to negatively charged molecules, supporting genomic integrity.
PRIMADINE
Oxford Healthspan's, Primeadine®, a plant-derived spermidine supplement.